Oleksandr Zinchenko is back in the starting line-up for the first time since the north London derby at the start of October.
The Ukraine international has missed nine games with a calf injury, but comes back into the side for the crunch trip to Stamford Bridge.
He’s one of seven changes from the side that beat FC Zurich on Thursday, joining Ben White, William Saliba and Gabriel in the back four.
Granit Xhaka is back from his European suspension to play in midfield with Thomas Partey and captain Martin Odegaard.
As usual, Gabriel Jesus is joined up front by Gabriel Martinelli and Bukayo Saka.
Arsenal: Ramsdale, White, Saliba, Gabriel, Zinchenko, Partey, Xhaka, Saka, Odegaard, Martinelli, Jesus
Subs: Turner, Cedric, Tierney, Holding, Elneny, Lokonga, Vieira, Nelson, Nketiah
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