Mikel Arteta has named the same side that saw off Leeds last weekend for the trip to Southampton.
It means six changes from the team that beat PSV Eindhoven in the Europa League in midweek.
Takehiro Tomiyasu will line up at left back again, with Ben White carrying on at right back. Gabriel, fresh from signing a new contract on Friday, partners William Saliba in the centre of defence.
Thomas Partey, Granit Xhaka and Martin Odegaard make up the midfield, up front Gabriel Martinelli and Bukayo Saka are either side of Gabriel Jesus.
The hosts have a number of injury problems, and are without Ainsley Maitland-Niles who is ineligible to face his parent club while on loan.
Their matchwinner from Wednesday’s victory over Bournemouth Che Adams is on the bench, with Adam Armstrong starting up front.
Arsenal: Ramsdale, White, Saliba, Gabriel, Tierney, Partey, Xhaka, Saka, Odegaard, Martinelli, Jesus.
Southampton: Bazunu, Perraud, Salisou, Calelta-Car, Lyanco, Elyounoussi, Ward-Prowse, Aribo, Diallo, A Armstrong, S Armstrong.
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