Arsene Wenger has made nine changes to the side that beat Stoke City in the Premier League on Sunday.
Thomas Vermaelen,Mikel Arteta and Lukasz Fabianski make their first starts this season and Nicklas Bendtner returns up front.
Elsewhere, Isaac Hayden makes his full debut for the Gunners and Serge Gnabry keeps his place in the team after impressing on his first start for the Gunners on Sunday.
Team in full: Fabianski, Jenkinson, Mertesacker, Vermaelen, Monreal, Arteta, Eisfeld, Hayden, Ryo, Bendtner, Gnabry
Subs: Viviano, Bellerin, Flamini, Olsson, Iwobi, Park, Akpom
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