Arsene Wenger has made one change to the side that beat Burnley 3-0 on Saturday.
Aaron Ramsey comes in for Mathieu Flamini as Arsenal move to a more attacking 4-1-4-1 formation.
The formation change sees Alexis Sanchez partner Ramsey in midfield while Mikel Arteta will take on defensive duties.
Arsenal team to play Anderlecht: Szczesny, Chambers, Mertesacker, Monreal, Gibbs, Ramsey, Arteta, Oxlade-Chamberlain, Alexis, Cazorla, Welbeck.
Substitutes: Martinez, Bellerin, Flamini, Rosicky, Podolski, Walcott, Sanogo
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