Mikel makes six changes to the side that beat Sheffield United at the weekend, including Jorginho who takes the responsibility of captain tonight.
Aaron Ramsdale who also featured in the third round against Brentford starts in goal tonight, with Gabriel returning to the starting eleven at the back.
Leandro Trossard, Fabio Vieira and Reiss Nelson are among the other changes made to the team to face West Ham at London Stadium.
Ramsdale, White, Kiwior, Gabriel, Zinchenko, Jorginho, Havertz, Vieira, Nelson, Trossard, Nketiah. Subs Hein, Cedric, Tomiyasu, Saliba, Rice, Elneny, Saka, Odegaard, Martinelli.
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