Arsene Wenger has made two changes to his side for the visit of Fenerbahce, with Jack Wilshere and Nacho Monreal in the starting XI.
The Gunners lead 3-0 from the first leg in Istanbul last Wednesday, but the boss has left little to chance by naming a strong side.
Spain international Monreal makes his first start of the season after recovering from a back injury, while Wilshere replaces Rosicky in midfield.
Elsewhere, Japanese winger Ryo is on the bench, alongside Laurent Koscielny who has recovered from the facial injury he sustained in Turkey.
Team in full: Szczesny, Jenkinson, Sagna, Merteacker, Monreal, Wilshere, Ramsey, Cazorla, Walcott, Giroud, Podolski
Subs: Fabianski, Gibbs, Koscielny, Rosicky, Frimpong, Ryo, Sanogo