Arsene Wenger has made four changes to the side that faced Olympiacos in the Champions League on Tuesday night with Petr Cech replacing David Ospina in goal.
Per Mertesacker is included in place of the injured Laurent Koscielny. Elsewhere, Aaron Ramsey and Nacho Monreal are recalled to the starting XI.
Theo Walcott retains his starting place as striker while Olivier Giroud, Alex Oxlade-Chamberlain and Joel Campbell are among those named as substitutes.
Arsenal team to play Manchester United: Cech, Bellerin, Mertesacker, Gabriel, Monreal, Coquelin, Cazorla, Ozil, Ramsey, Alexis, Walcott
Arsenal subs: Ospina, Debuchy, Gibbs, Oxlade-Chamberlain, Chambers, Campbell, Giroud