Arsene Wenger has made three changes to the side that beat Anderlecht 2-1 on Wednesday.
Wojciech Szczesny returns from suspension to replace Emiliano Martinez in goal while Mikel Arteta and Alex Oxlade-Chamberlain come in for Aaron Ramsey and the suspended Jack Wilshere.
Elsewhere, Theo Walcott returns to the first-team squad to take his place on the bench alongside Wendesday’s match winner, Lukas Podolski.
Team in full: Szczesny, Chambers, Mertesacker, Monreal, Gibbs, Arteta, Flamini, Oxlade-Chamberlain, Cazorla, Alexis, Welbeck
Substitutes: Martinez, Bellerin, Ramsey, Campbell, Rosicky, Walcott, Podolski