Jorginho comes in to make his first Premier League start of the season in the eagerly anticipated visit of Manchester City.
The Italian midfielder is one of three changes to the side that lost in Lens in the Champions League on Tuesday.
However, here is no place in the matchday squad for Bukayo Saka, who was taken off in the first half in France, and the winger thus ends a run of 87 consecutive Premier League appearances.
Ben White returns to the defence, in place of Takehiro Tomiyasu, while Eddie Nketiah returns up front. Kai Havertz drops to the bench.
Gabriel Martinelli is also among the substitutes, after missing five games through injury.
For the visitors, top scorer Erling Haaland leads the line up front as usual, while midfielder Rodri is suspended.
Arsenal: Raya, White, Saliba, Gabriel, Zinchenko, Rice, Jorginho, Odegaard, Trossard, Jesus, Nketiah. Subs: Ramsdale, Kiwior, Tomiyasu, Partey, Smith Rowe, Vieira, Nelson, Havertz, Martinelli.
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