Arsene Wenger has made two changes to the side that beat Borussia Dortmund for the trip to Manchester United.
Mathieu Flamini is fit again and starts in midfield, while Thomas Vermaelen partners Laurent Koscielny at the back.
Elsewhere, Jack Wilshere returns to the bench, where there is also space for youngsters Isaac Hayden and Serge Gnabry.
Per Mertesacker and Tomas Rosicky are ruled out through illness.
Team in full: Szczesny, Sagna, Koscielny, Vermaelen, Gibbs, Arteta, Flamini, Ramsey, Cazorla, Ozil, Giroud.
Subs: Fabianski, Jenkinson, Monreal, Hayden, Gnabry, Wilshere, Bendtner
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