Shkodran Mustafi and Lucas have been handed their debuts against Southampton at Emirates Stadium.
Laurent Koscielny partners Mustafi in the centre of defence, while Francis Coquelin steps into midfield alongside Santi Cazorla.
Lucas leads the line in attack, while Theo Walcott and Alex Oxlade-Chamberlain start on the wings.
Arsenal team: Cech, Bellerin, Koscielny, Mustafi, Monreal, Cazorla, Coquelin, Walcott, Ozil, Oxlade-Chamberlain, Lucas
Arsenal substitutes: Ospina, Holding, Elneny, Xhaka, Iwobi, Alexis, Giroud
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