Arsene Wenger makes three changes to the side that beat Monaco 2-0 on Tuesday.
Calum Chambers replaces Hector Bellerin at right back while Gabriel also comes in for Per Mertesacker.
Mesut Ozil misses the game through illness so Aaron Ramsey returns to the starting lineup and Santi Cazorla plays behind Olivier Giroud.
Full team: Ospina, Chambers, Gabriel, Koscielny, Monreal, Coquelin, Ramsey, Alexis, Cazorla, Welbeck, Giroud
Subs: Szczesny, Gibbs, Mertesacker, Bellerin, Flamini, Rosicky, Walcott