Arsene Wenger makes nine changes to the side that lost to Southampton on Tuesday.
Per Mertesacker, Laurent Koscielny and Kieran Gibbs return to the back four, while Mikel Arteta comes in to parter Jack Wilshere in the middle.
There are also returns for Aaron Ramsey, Mesut Ozil, Alex Oxlade-Chamberlain and Danny Welbeck.
The full team is as follows: Szczesny, Chambers, Mertesacker, Koscielny, Gibbs, Wilshere, Arteta, Ramsey, Ozil, Oxlade-Chamberlain, Welbeck.
Substitutes: Ospina, Coquelin, Flamini, Rosicky, Podolski, Cazorla, Alexis
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