Arsene Wenger has made 10 changes to the side that beat Aston Villa 3-0 on Saturday.
David Ospina makes his Arsenal debut while Abou Diaby returns from a long-term injury and Calum Chambers starts against his old club.
Elsewhere, under-21 regulars Hector Bellerin, Isaac Hayden, Francis Coquelin and Joel Campbell also come into the side.
Team in full: Ospina, Bellerin, Chambers, Hayden, Coquelin, Rosicky, Diaby, Wilshere, Alexis, Campbell, Podolski
Substitutes: Martinez, Ajayi, Gibbs, Mertesacker, Oxlade-Chamberlain, Cazorla, Akpom
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