Arsene Wenger has made 10 changes for our Emirates FA Cup tie at Southampton.
Shkodran Mustafi keeps his place but Alexis is on the bench and Mesut Ozil, Laurent Koscielny, Olivier Giroud, Francis Coquelin and Aaron Ramsey are not with the squad.
Ainsley Maitland-Niles and Alex Oxlade-Chamberlain will pair up in central midfield, with Jeff Reine-Adelaide in the No 10 role.
Danny Welbeck makes his first start of the season, Theo Walcott is back in the line-up and club captain Per Mertesacker returns to the squad.
Arsenal team: Ospina, Bellerin, Mustafi, Holding, Gibbs, Maitland-Niles, Oxlade-Chamberlain, Reine-Adelaide, Walcott, Lucas, Welbeck
Subs: Martinez, Gabriel, Monreal, Alexis, Iwobi, Jenkinson, Mertesacker
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