Arsene Wenger has made eight changes to his starting XI for the game at Sheffield Wednesday in the Capital One Cup.
Academy products Glen Kamara and Alex Iwobi make their competitive debuts while Per Mertsacker returns to the team having recovered from illness.
Petr Cech, Kieran Gibbs, Mathieu Debuchy, Calum Chambers, Mathieu Flamini and Joel Campbell all start while Olivier Giroud retains his role as striker.
Starting XI: Cech, Gibbs, Mertesacker, Chambers, Debuchy, Flamini, Kamara, Campbell, Oxlade-Chamberlain, Iwobi, Giroud
Substitutes: Macey, Gabriel, Monreal, Bielik, Sheaf, Bennacer, Walcott