Arsene Wenger has made three changes to the side that drew 0-0 against Liverpool at Emirates Stadium on Monday.
Laurent Koscielny has overcome a mild back injury to start alongside Gabriel in place of Calum Chambers, while Alex Oxlade-Chamberlain comes in for Mesut Ozil, who misses the game with a minor knee problem.
Elsewhere, Theo Walcott replaces Olivier Giroud up front to lead the line at St James’ Park.
Arsenal team to play Newcastle: Cech, Bellerin, Gabriel, Koscielny, Monreal, Coquelin, Ramsey, Oxlade-Chamberlain, Cazorla, Alexis, Walcott
Arsenal subs: Ospina, Debuchy, Gibbs, Chambers, Arteta, Campbell, Giroud
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