Arsene Wenger has made five changes to the side that beat Queens Park Rangers 2-1 on Wednesday.
Wojciech Szczesny replaces David Ospina in goal while Laurent Koscielny and Nacho Monreal come in for Gabriel and Kieran Gibbs.
Elsewhere, Alex Oxlade-Chamberlain returns to the starting lineup at the expense of Tomas Rosicky while Danny Welbeck starts ahead of Olivier Giroud.
Full team: Szczesny, Bellerin, Mertesacker, Koscielny, Monreal, Coquelin, Cazorla, Oxlade-Chamberlain, Ozil, Alexis, Welbeck
Subs: Martinez, Gibbs, Chambers, Ramsey, Giroud, Walcott, Akpom
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