Arsene Wenger has made five changes to the side that lost 3-2 against Stoke City on Saturday.
Wojciech Szczesny comes in for Emiliano Martinez while fit-again Mathieu Debuchy replaces Kieran Gibbs, which sees Hector Bellerin switch to left back.
Mathieu Flamini, Alex Oxlade-Chamberlain and Aaron Ramsey retain their places but there are starts for Joel Campbell, Lukas Podolski and Yaya Sanogo in attack.
Elsewhere, Wenger has named a youthful bench with six under-21 players listed.
Arsenal team to play Galatasaray: Szczesny, Debuchy, Chambers, Mertesacker, Bellerin, Flamini, Campbell, Oxlade-Chamberlain, Ramsey, Podolski, Sanogo
Subs: Martinez, O’Connor, Kamara, Maitland-Niles, Zelalem, Iwobi, Akpom