Arsene Wenger has made three changes to the side that beat Southampton 1-0 on Wednesday.
Laurent Koscielny drops to the bench which sees Calum Chambers move into centre back and Hector Bellerin come in on the right.
Kieran Gibbs makes his 100th Premier League appearance for Arsenal in place of Nacho Monreal and Olivier Giroud comes in for Danny Welbeck.
Elsewhere, under-21s Semi Ajayi and Ainsley Maitland-Niles start the game on the bench.
Full team below:
Team to play Stoke: Martinez, Bellerin, Chambers, Mertesacker, Gibbs, Flamini, Ramsey, Oxlade-Chamberlain, Alexis, Cazorla, Giroud
Subs: Szczesny, Koscielny, Ajayi, Maitland-Niles, Campbell, Podolski, Welbeck
Copyright 2020 The Arsenal Football Club plc. Permission to use quotations from this article is granted subject to appropriate credit being given to www.arsenal.com as the source.