Arsène Wenger will crunch the numbers and consult his players before confirming his team to face Norwich City.
The Arsenal manager has been welcoming his international stars back to the training ground after the final round of World Cup qualifiers, and some have had heavier workloads than others since their last club match.
Wenger will speak to his medical staff to see which players may need to sit out Saturday's game.
"We start to look at it [the minutes each player has played] and you get their [the players'] feeling as well," Wenger told Arsenal Player.
"You add that to the number of minutes they have played since the start of the season, then you make your decisions.
"Overall we do not come off it [the international break] too bad because Koscielny didn't play the first game at all, Giroud played only one half and 80 minutes in the second.
"The only one who played again over the two games is Aaron Ramsey, and apart from that Mertesacker played only one, Ozil played nearly two full games.
"You look at it [the numbers] because we play so many games now. That's why it's important to have players like Cazorla, like Rosicky and hopefully Walcott, Podolski and Chamberlain back soon."