The latter centre back captained Belgium in their defeats to Germany and Turkey over the weekend but came back with a short-term problem.
However, while Vermaelen was playing in Istanbul on Tuesday night, Squillaci was featuring in his first game in an Arsenal shirt as the Reserves beat Blackburn 4-3 at Barnet.
At his press conference on Friday, Wenger confirmed the French international would make his first-team bow at Emirates Stadium this weekend.
"He will play tomorrow," said the manager. "I know Sebastien very well and the target was to give him 90 minutes for the Reserves. Just to get his positional play back.
"He is experienced and it is good he can compensate the absence of Vermaelen tomorrow.
"Vermaelen's [injury] should be short-term and has a chance to play on Wednesday night."
Wenger also confirmed that Samir Nasri will return after knee surgery.
"Nasri is back in the squad, which is quicker than expected," said the manager. "It is not often you can give this kind of news. We are happy he is back."
Theo Walcott and Robin van Persie both have ankle injuries which will sideline them for four to six weeks. Nicklas Bendtner (groin) will be out for a further three or four weeks. Aaron Ramsey (broken leg) is on course to return in November.Copyright 2013 The Arsenal Football Club plc. Permission to use quotations from this article is granted subject to appropriate credit being given to www.arsenal.com as the source 10 Sep 2010