Wilshere has been out for 14 months with ankle and knee injuries, but makes his first appearance in midfield in place of Francis Coquelin.
Sagna, meanwhile, was sidelined after fracturing his fibula against Norwich on May 5, but comes back to replace Carl Jenkinson at right back.
Elsewhere, Olivier Giroud spearheads the attack as Gervinho drops to the bench.
Team in full: Mannone, Sagna, Vermaelen, Mertesacker, Santos, Arteta, Wilshere, Ramsey, Cazorla, Podolski, Giroud.
Subs: Martinez, Koscielny, Jenkinson, Coquelin, Walcott, Arshavin, Gervinho.Copyright 2014 The Arsenal Football Club plc. Permission to use quotations from this article is granted subject to appropriate credit being given to www.arsenal.com as the source 27 Oct 2012