The Polish goalkeeper and Swiss defender were expected to miss the rest of the season after suffering finger and shoulder injuries respectively last month.
But Szczesny and Djourou have recovered sooner than expected and step in for Jens Lehmann and Sebastien Squillaci.
Alex Song is also back in the squad but will start on the bench alongside Andrey Arshavin, who makes way for Theo Walcott.
Arsenal team: Szczesny, Eboue, Koscielny, Djourou, Clichy, Diaby, Wilshere, Walcott, Fabregas, Nasri, Van Persie. Subs: Lehmann, Song, Squillaci, Arshavin, Gibbs, Chamakh, BendtnerCopyright 2016 The Arsenal Football Club plc. Permission to use quotations from this article is granted subject to appropriate credit being given to www.arsenal.com as the source