Song and Gervinho return from domestic suspension while youngsters Frimpong and Jenkinson continue after impressing against Liverpool.
Robin van Persie, who was suspended for the first leg last week, also starts in Italy.
Team in full: Szczesny, Jenkinson, Vermaelen, Djourou, Sagna, Song, Frimpong, Ramsey, Walcott, Gervinho, Van Persie.
Subs: Fabianski, Traore, Miquel, Rosicky, Oxlade-Chamberlain, Arshavin, Chamakh.Copyright 2016 The Arsenal Football Club plc. Permission to use quotations from this article is granted subject to appropriate credit being given to www.arsenal.com as the source