The Swedish midfielder has been absent with a hamstring strain for nearly two months while the Belarus winger picked up a similar problem in the Carling Cup Semi-Final first leg on January 24.
Johan Djourou is available despite suffering a nasty bang on the nose in the 2-1 win at Wigan on Sunday. However Mathieu Flamini is out with an ankle problem. Wenger will leave out Jens Lehmann and Thierry Henry but, aside from that, Arsenal will be at full strength.
"I will rest Lehmann, because Almunia plays, and Henry," Wenger told Arsenal TV Online on Tuesday afternoon. "But everyone else will play.
"Djourou is available. Freddie Ljungberg and Alex Hleb are back in the squad for Bolton but Eboue and Gallas are still not ready. Flamini is out with an ankle problem."
Arsenal TV Online subscribers will be able to see the full video interview on Wednesday morning. In it, the Arsenal manager talks about: the fallout from the Wigan game, accommodating the FA Cup in a hectic schedule, whether the Bolton bogey exists, Nicolas Anelka and the form of Gael Clichy.
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