Arsenal will be without four of their heroes from Villarreal for the game at Sunderland on Monday afternoon.
Alex Hleb (knee) is doubtful while Gilberto (ankle) and Mathieu Flamini (hamstring) are definitely out. Jose Antonio Reyes will also be missing after having his wisdom teeth out. On the upside, Ashley Cole is likely to be included in the first team squad for only the second time since October 2.
All the newly injured players could be fit for Thursday's trip to Manchester City. However Philippe Senderos, who injured his knee against Tottenham last Saturday, is expected to be missing for three weeks. Theo Walcott suffered a knee injury himself in the Reserves on Thursday night and will not be involved at the Stadium of Light.
"We have a few injuries," said Wenger at Friday's pre-match press conference. "Alexander Hleb is doubtful for Monday, he has a little knee problem. Gilberto will be out certainly with an ankle problem.
"We have Flamini (hamstring), Senderos (knee) and Reyes, with the extraction of his wisdom teeth. But they could be back on Thursday.
"Theo Walcott got injured in the Reserves last night and came off after 10 minutes, but we think it will be a question of days rather than weeks."
Cole played another 90 minutes in that 3-1 victory at West Ham. Having not had a recognised left back for six months, Wenger now has two. Gael Clichy came on for the injured Flamini at El Madrigal on Tuesday.
"Ashley played last night and came through well," said Wenger. "He had no problem today, and will be available for Monday.
"At the back I do not think there will be lot to change, maybe Ashley can come in I do not know yet but Clichy has done well. Sol Campbell will play at centre back though."
Copyright 2015 The Arsenal Football Club plc. Permission to use quotations from this article is granted subject to appropriate credit being given to www.arsenal.com as the source 28 Apr 2006