Arsène Wenger has explained the major absences in his squad for the trip to FC Twente on Wednesday.
Arsenal are missing five major names and the long-term sidelined Tomas Rosicky and Eduardo.
It leaves the Frenchman relying on youngsters like Aaron Ramsey and Denilson to inspire his squad to a crucial victory in Holland.
"We have a big squad at home" said Wenger.
"Kolo has a hip muscle problem. Cesc has a hamstring problem, he will be out for the next two games.
"Abou Diaby (thigh) will be out for a while, we knew that. Philippe Senderos has a scan on his hamstring. He did that today whereas Fabregas did his hamstring yesterday.
"Samir Nasri (knee/thigh) should be OK for Saturday and so should Kolo Toure".
When asked who was likely to come in as a replacement the manager replied "Aaron Ramsey has a good chance to start".
Robin VAN PERSIE