Arsenal were victorious last time out in the league, beating West Brom 2-0 at Emirates Stadium, and travel to Madejski Stadium in the knowledge that they have won their last 10 games against the Royals in all competitions.
Reading have won just one of their last 10 Premier League games at Madejski Stadium, losing their last five in succession.
Theo Walcott scored a hat-trick the last time the teams met, and is 13/2 with GunnersGaming to score the opener, and 2/1 to net at any time - provided he recovers from a calf injury in time to play a part.
Otherwise, Lukas Podolski can be backed at 11/2 in the first goalscorer market.
Reading have managed just one clean sheet in the league all season, the lowest tally of all Premier League sides, so over 2.5 goals at 7/12 also looks well worth considering.
*Odds correct at time of writing. Terms and conditions apply.