Arsenal have lost only two of their last 43 Champions League home games since 2003, with both of those defeats coming against English clubs.
Schalke have won just one of their last eight European games against English teams (W1, D1, L6) and have also failed to score in four of their last five games against English opponents.
The last time the two sides met in this competition was in the 2001/02 Group Stage, when Arsenal won 3-2 at home before losing 1-3 in Gelsenkirchen.
One real positive as far as the Gunners are concerned is that they currently have the best conversion rate in the competition so far, scoring with 36 per cent of their shots - and face a side who have conceded on the three occasions their opponents have managed shots on target.
Lukas Podolski has scored four goals in his last three Champions League matches and is a 13/10 chance with GunnersGaming to get on the scoresheet. He can also be backed at 11/2 to net the opening goal.
Olivier Giroud is 6/1 second favourite in the first goalscorer market, while Sant Cazorla is an 8/1 chance.
*Odds correct at time of writing. Terms and conditions apply.