Arsène Wenger's side won 2-0 at Liverpool last time out, after drawing their first two league games.
New signings Lukas Podolski and Santi Cazorla impressed in the Gunners' 2-0 win at Anfield, with both scoring their first goal for the club.
Cazorla is 11/2 to score the opener.
Arsenal have only ever lost two home league games against Southampton.
The home side are also the only team not to have conceded in the top flight, and are 49/10 to win 2-0.
Southampton put up spirited shows in defeats against the two Manchester clubs, scoring against both, so 2-1 is worth a second look at 38/5.
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