Arsene Wenger has made six changes to the side that faced Dinamo Zargreb in the Champions League.
Petr Cech replaces David Ospina in goal and Theo Walcott starts as striker with Olivier Giroud on the bench.
Elsewhere, Hector Bellerin, Nacho Monreal, Francis Coquelin and Aaron Ramsey are all included in the starting XI.
Arsenal team to play Chelsea: Cech, Bellerin, Gabriel, Koscielny, Monreal, Coquelin, Ramsey, Cazorla, Alexis, Ozil, Walcott
Arsenal subs: Ospina, Debuchy, Gibbs, Arteta, Giroud, Oxlade-Chamberlain, Chambers
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